BIOP: Fluctuations, Regulations and Evolution of Living Systems

Team members | Scientific production | M2Bio platform | Former members

The BIOP team is a multidisciplinary team of physicists and biologists. It addresses fundamental questions about biological systems by combining quantitative experimental approaches, modeling and theoretical approaches.

In different ways, we study the dynamics and adaptation of biological systems to a changing environment. In order to understand the fundamental mechanisms of life, we not only study natural systems at different scales (from molecular biology to ecosystems) but we also build the components of very well defined systems (genetic circuits, antibodies, bacterial consortia, ...). Our research benefits from this combination of fundamental research and engineering and from the close interaction between biology, physics and mathematical modeling.

Regulation, engineering and control of microbial systems

Adaptation and control of growth

Regulation of bacterial growth (JG, HdJ, DR, SL, EC)
Modeling the variability of microbial growth (AM, EC)
Resources allocation strategies in microorganisms (EC, JG, HdJ, AM, DR, NS)
Stress response and biofilm formation in E. coli (SL)

RNA

Small RNAs and gene regulation in E. coli (SL, AD)
Global post-transcriptional regulations in E. coli (DR, SL)
RNA synthetic biology (AD)

Evolution and ecosystems

Synthetic bacterial ecosystems (EC, JG, HdJ, AM)
Directed evolution by phage display (NS)
Dynamical models of ecosystems (DR, EC, HdJ)
Ecosystems, biodiversity and population genetics (BH)

Biotechnology, instrumentation and computational methods

Mini-bioreactors (EC, JG, HdJ, NS)
Engineering of bacterial genomes (CB, JG, NS, AD, SL, DR, HdJ)
Microfluidic devices for the selection of bio-recognition elements (GG, NS)
Production optimization for biotechnologies (JG, EC, HdJ, DR)
Statistical analysis tools for microbial growth and gene expression data (AM, EC)