BIOP: Fluctuations, Regulations and Evolution of Living Systems

Team members | Scientific production | M2Bio platform | Former members

The BIOP team is a multidisciplinary team of physicists and biologists. It addresses fundamental questions about biological systems by combining quantitative experimental approaches, modeling and theoretical approaches.

In different ways, we study the dynamics and adaptation of biological systems to a changing environment. In order to understand the fundamental mechanisms of life, we not only study natural systems at different scales (from molecular biology to ecosystems) but we also build the components of very well-defined systems (genetic circuits, antibodies, bacterial consortia, ...). Our research benefits from this combination of fundamental research and engineering and from the close interaction between biology, physics and mathematical modeling.

Evolution and Ecosystems

Stochastic approaches to evolution (BH)
Directed evolution by phage display (NS)
Natural bacterial ecosystems (DR, EC, HdJ)
Synthetic bacterial ecosystems (EC, JG, HdJ, AM)

Cells

Resource allocation strategies in microorganisms (EC, JG, HdJ, AM, DR, NS)
Modeling the variability of microbial growth (AM, EC)

Molecules

Small RNAs and gene regulation in E. coli (SL, AD)
Synthetic biology of RNA (AD)
Stress response and biofilm formation in E. coli (SL)
Genome-scale analysis of microbial physiology (DR, SL)

Biotechnology, instrumentation and computational methods

Mini-bioreactors (EC, JG, HdJ, NS)
Engineering of bacterial genomes (CB, JG, NS, AD, SL, DR, HdJ)
Microfluidic devices for the selection of bio-recognition elements (GG, NS)
Production optimization for biotechnologies (JG, EC, HdJ, DR)
Statistical analysis tools for microbial growth and gene expression data (AM, EC)