BIOP: Fluctuations, Regulations and Evolution of Living Systems

In different ways, we study the dynamics and adaptation of biological systems to a changing environment. In order to understand the fundamental mechanisms of life, we not only study natural systems at different scales (from molecular biology to ecosystems) but we also build the components of very well-defined systems (genetic circuits, antibodies, bacterial consortia, ...). Our research benefits from this combination of fundamental research and engineering and from the close interaction between biology, physics and mathematical modeling.

• Stochastic approaches to evolution
• Directed evolution by phage display
• Natural bacterial ecosystems
• Synthetic bacterial ecosystems

• Resource allocation strategies in microorganisms
• Modeling the variability of microbial growth

• Small RNAs and gene regulation in E. coli
• Synthetic biology of RNA
• Stress response and biofilm formation in E. coli
• Genome-scale analysis of microbial physiology

• Mini-bioreactors
• Engineering of bacterial genomes
• Microfluidic devices for the selection of bio-recognition elements
• Production optimization for biotechnologies
• Statistical analysis tools for microbial growth and gene expression data