Small RNAs and gene regulation in E. coli

Stéphan Lacour

We are studying the global regulatory effects of RpoS and its cofactors (Crl and an uncharacterized protein) in E. coli K12. In particular, we are looking for antisense RNAs and non-coding RNAs (RNAseq) and transcription factors responsible for indirect gene regulation, including negative regulation. We are also trying to identify the core of the RpoS regulator (Run Off Micro Array, ChIP-seq) in order to determine the specific characteristics and properties of the DNA of promoters strictly dependent on RpoS.

Collaborations

Paolo Landini (Università degli Studi di Milano, Italy), Clelia Peano (ITB, National Research Council, Segrate (MI), Italy), Magne Osteris (Fasteris, Geneva, Switzerland)

Stéphan Lacour, Alexandre Dawid

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