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How can the hidden light of living tissue be decoded?

Publication Research On November 26, 2025

This is the challenge facing the ANR FULBOX project, led by Bastien Arnal, a CNRS researcher at LIPhy, which aims to develop new tools for imaging biological tissues in depth using photoacoustic imaging techniques.

For more information, see:

  • the article published in Echosciences Grenoble,
  • the video “Concentré de sciences” produced by CNRS Alpes.

FULBOX
Crédit: KAM Production

Contact

Bastien ARNAL (OPTIMA team)
bastien.arnalatuniv-grenoble-alpes.fr (bastien[dot]arnal[at]univ-grenoble-alpes[dot]fr)

Understanding the mechanical response of foams by observing individual bubbles

Publication Research On November 5, 2025

By observing sheared foam under a time-resolved X-ray tomograph, researchers were able to observe how the rearrangements of bubbles in flow cause the overall mechanical response of the entire system.

For more information, visit:

  • the news on the CNRS Physique website,
  • the scientific paper published in open access in Nature Communications.
Mousse

Contact

Stephane SANTUCCI (LPENSL)
stephane.santucciatens-lyon.fr (stephane[dot]santucci[at]ens-lyon[dot]fr)

Christophe RAUFASTE (INPHYNI)
christophe.raufasteatuniv-cotedazur.fr (christophe[dot]raufaste[at]univ-cotedazur[dot]fr)

Benjamin DOLLET (LIPhy)
benjamin.dolletatuniv-grenoble-alpes.fr (benjamin[dot]dollet[at]univ-grenoble-alpes[dot]fr)

Reference

F. Schott, B. Dollet, S. Santucci, C. M. Schlepütz, C. Claudet, S. Gstöhl, C. Raufaste & R. Mokso. Multiscale stress dynamics in sheared liquid foams revealed by tomo-rheoscopy. Nat. Commun. 16(1), 9210 (2025)

Researchers reveal the mechanism by which copper nanoparticles degrade bacterial membranes

Publication Research On November 4, 2025

An international team of researchers from LIPhy (Université Grenoble Alpes / CNRS), the Institut des Molécules et Matériaux du Mans (Le Mans Université / CNRS) and the Technische Universität Darmstadt (Germany) has shown that copper-based nanoparticles (Cu(OH)₂) can degrade bacterial membranes in presence of small amounts of hydrogen peroxide – amounts comparable to those naturally produced by the metabolism of bacterial cells.

Using neutron reflectometry, the researchers were able to observe in detail the transformation of the membrane upon exposure to the nanoparticles. The results show that more than half of the lipid bilayer that constitutes the bacterial membrane is destroyed, leaving only a single layer of lipids – a clear sign of true membrane lysis (rupture).

This study proposes a simple yet highly precise method for investigating the effects of nanoparticles on cellular membranes. It could notably help to better understand the role of nanostructured materials in the fight against bacteria, by testing different membrane compositions, various types of nanoparticles, and diverse oxidative environments.

For more information, see the scientific article published in open access in Soft Matter.

Membrane

Contact

Samantha MICCIULLA
samantha.micciullaatuniv-grenoble-alpes.fr (samantha[dot]micciulla[at]univ-grenoble-alpes[dot]fr)

Reference

S. Micciulla, H. Robertson, N. Paracini & G. Corbel. Oxidative destabilization of model E. coli membrane by Cu(OH)2 nanoparticles: a neutron reflectometry study. Soft Matter (2025)

Giant mobility of surface-trapped ionic charges revealed by sliding water droplets

Publication Research On October 23, 2025

A team of researchers from ESPCI Paris (CNRS/PSL/Sorbonne Université) and the Laboratoire Interdisciplinaire de Physique (CNRS/Université Grenoble Alpes) combined high-resolution electrostatic mapping with molecular dynamics simulations to investigate the behavior of these surface-trapped ionic charges. They found that the ionic charges spread across the surface with astonishing mobility. Their two-dimensional diffusion far exceeds that of ions in bulk water, with the limiting factor being the friction between the ionic solvation shell and the solid.

These findings, published in Proceedings of the National Academy of Sciences, reveal the existence of a new state of interfacial ionic matter, which the authors term “ionic puddles.”

For more information, visit:

  • the news on the CNRS Physique website,
  • the scientific paper in Proceedings of the National Academy of Sciences.
Electrostatic mapping of surface charges
Electrostatic mapping (short times on the left, long times on the right) of surface charges deposited in the wake of a water droplet sliding on a hydrophobic solid. Their lateral diffusion over time highlights a remarkably high mobility.

Contact

Simon GRAVELLE
simon.gravelleatuniv-grenoble-alpes.fr (simon[dot]gravelle[at]univ-grenoble-alpes[dot]fr)

Reference

Z. Benrahla, T. Saide, L. Burnaz, E. Verneuil, S. Gravelle, & J. Comtet. Giant mobility of surface-trapped ionic charges following liquid tribocharging. Proc. Natl. Acad. Sci. U.S.A. 122(37), e2505841122 (2025)

 

Tau: Not Just a Stabilizer, But an Active Microtubule Remodeler

Publication Research On October 4, 2025

An interdisciplinary team of researchers from Germany and the LIPhy has demonstrated that Tau, a neuronal protein known for stabilizing microtubule tips, plays an active role in modulating microtubule lattice dynamics. The study reveals that Tau significantly accelerates the exchange of tubulin within the microtubule lattice, especially at topological defect sites, despite lacking enzymatic activity. These findings challenge the traditional view of Tau as merely a passive stabilizer, showing instead that it increases lattice anisotropy and, in doing so, actively enhances microtubule lattice dynamics.

To find out more, take a look at the scientific article published in Nature Physics.

Tau: Not Just a Stabilizer, But an Active Microtubule Remodeler

Contact

Karin JOHN
karin.johnatuniv-grenoble-alpes.fr (karin[dot]john[at]univ-grenoble-alpes[dot]fr)

Reference

S. Biswas, R. Grover, C. Reuther, C. S. Poojari, R. Shaebani, S. Nandakumar, M. Grünewald, A. Zablotsky, J. S. Hub, S. Diez, K. John & L. Schaedel. Tau accelerates tubulin exchange in the microtubule lattice. Nat. Phys. 1745-2481 (2025)

How not to let CO2 bubbles over in the air

Publication Research On September 15, 2025

A team from LIPhy has studied the transport of CO2 within a liquid foam in contact with the atmosphere and shown how its effective diffusion in the medium emerges from the coupling between the structure of the foam and the transport of the gas through the soap films. This study paves the way for the development of low-cost CO2 filtration systems based on the ability of this main contributor to the greenhouse effect to dissolve more easily in water than most other gases.

For more information, have a look at:

foam

Contact

Benjamin Dollet
simon.gravelleatuniv-grenoble-alpes.fr (benjamin[dot]dollet[at]univ-grenoble-alpes[dot]fr)

Reference

C. Aprili, G. Coupier, É. Lorenceau, & B. Dollet, Tunable effective diffusion of CO2 in aqueous foam. Proc. Natl. Acad. Sci. U.S.A. 122(35), e2504617122 (2025)

The Matosthèque, LIPhy's initiative to reduce the environmental footprint of equipment purchases

Publication Research On September 2, 2025

LIPhy is taking action to reduce the share of equipment purchases in its CO2 emissions! Over the past year, the laboratory has developed and implemented a new digital tool for sharing equipment: the Matosthèque.

The laboratory's tutelles support this initiative! To find out more, take a look at:

  • the news published by CNRS,
  • the news published by UGA.

Other laboratories are already considering deploying the tool within their organizations:

  • Matière et Systèmes Complexes - CNRS Physique / CNRS Ingénierie – DR01
  • Institut Néel - CNRS Physique – DR11
  • Institut Lumière Matière - CNRS Physique – DR07
  • Laboratoire de Biologie Tissulaire et d’Ingénierie thérapeutique - CNRS Biologie – DR07
  • Institut Jacques Monod - CNRS Biologie – DR01
  • Observatoire des Sciences de l'Univers Terre Homme Environnement Temps Astronomie - CNRS Terre&Univers – DR06

Soon the export of the Matosthèque on a large scale?

Matosthèque

Contact

Guillemin RAYMOND
guillemin.raymondatuniv-grenoble-alpes.fr (guillemin[dot]raymond[at]univ-grenoble-alpes[dot]fr)

Vikhram DUFFOUR
vikhram-kofi.duffouratuniv-grenoble-alpes.fr (vikhram-kofi[dot]duffour[at]univ-grenoble-alpes[dot]fr) 

Tooth sensitivity, a network issue?

Publication Research On July 18, 2025

Dental sensitivity is unique in that it is mediated by cells called odontoblasts, located in the dental pulp at the center of the tooth. According to hydrodynamic theory, the activation of odontoblastic processes is linked to the movement of fluids in the dentinal porosity induced by external stimuli. A new study conducted at the Interdisciplinary Laboratory of Physics (LIPhy - CNRS/UGA) shows that this porosity has all the characteristics of a complex network. Far from functioning as independent sensors, odontoblasts could therefore, in theory, adopt collective behaviors that are very different from the simple sum of individual responses.

To find out more, take a look at :

Tooth

Contact

Aurélien GOURRIER
aurelien.gourrieratuniv-grenoble-alpes.fr (aurelien[dot]gourrier[at]univ-grenoble-alpes[dot]fr)

Reference

L. Chatelain, N. Tremblay, E. Vennat, E. Dursun, D. Rousseau & A. Gourrier. Cellular porosity in dentin exhibits complex network characteristics with spatio-temporal fluctuations. PLOS One 20(7), e0327030 (2025)

Artificial intelligence for optical measurements at the ultimate limit of precision

Publication Research On June 25, 2025

When light is scattered, how accurately can a measurement result be derived from that light? An international research team has explored the limits of what is possible using artificial intelligence.

To find out more, take a look at :

Measurement AI

Contact

Dorian BOUCHET
dorian.bouchetatuniv-grenoble-alpes.fr (dorian[dot]bouchet[at]univ-grenoble-alpes[dot]fr)

Reference

I. Starshynov, M. Weimar, L. M. Rachbauer, G. Hackl, D. Faccio, S. Rotter & D. Bouchet. Model-free estimation of the Cramér–Rao bound for deep learning microscopy in complex media. Nature Photonics 19, 593-600 (2025)

Universal Laws of Swimming – From Microbes to Whales

Publication Research On June 12, 2025

A scientific team from Grenoble, involving the Laboratoire interdisciplinaire de physique (LIPhy - CNRS/UGA) and the Centre Inria de l'UGA, has developed a groundbreaking computational model that reveals universal laws governing how creatures swim across vastly different sizes and environments — from microscopic bacteria to massive blue whales.

To find out more, take a look at :

Poisson

Contact

Bruno VENTEJOU
bruno.ventejouatuniv-grenoble-alpes.fr (bruno[dot]ventejou[at]univ-grenoble-alpes[dot]fr)

Reference

B. Ventéjou, T. Métivet, A. Dupont & P. Peyla. Universal Scaling Laws for a Generic Swimmer Model. Physical Review Letters 134(13), 134002 (2025)

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