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The interaction between macrophages and their environment affects their functioning

Publication Research On March 27, 2025

Macrophages are immune system cells that ingest and degrade microorganisms and cellular debris in a process called phagocytosis. In a study published in iScience, scientists show that the mechanical properties of the tissues surrounding macrophages influence phagocytosis, which in turn affects the way macrophages interact with their environment.

To find out more, take a look at :

  • the news published on the CNRS Biologie website,
  • the scientific article published in Nature Microbiology.
macrophages

Contact

Isabelle Tardieux (IAB, Grenoble)
isabelle.tardieuxatinserm.fr (isabelle[dot]tardieux[at]inserm[dot]fr)

Galina Dubacheva (DCM, Grenoble)
galina.dubachevaatuniv-grenoble-alpes.fr (galina[dot]dubacheva[at]univ-grenoble-alpes[dot]fr)

Delphine Débarre (LIPhy, Grenoble)
delphine.debarreatuniv-grenoble-alpes.fr (delphine[dot]debarre[at]univ-grenoble-alpes[dot]fr)

 

Reference

L. Vigetti, B. Touquet, L. Bureau, D. Abdallah, I. Tardieux , D. Debarre, T. Rose, G. V. Dubacheva. Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility. Nature Microbiology 9, 3148 (2024)

Recording the absorption spectra of gaseous molecules with an optical cavity of high finesse

Publication Research On February 20, 2025

To better understand the formation, composition and evolution of the atmospheres of terrestrial planets, scientists at LIPhy have developed spectrometers using optical cavity spectroscopy (CRDS). Their high sensitivity enables them to accurately record the absorption spectra of various molecules of atmospheric and planetary interest, such as dihydrogen, water or methane, mixed with carbon dioxide.

This research was funded in whole or in part by the French National Research Agency (ANR) under the COMPLEAT project, coordinated by Didier Mondelain, a CNRS researcher at LIPhy.

To find out more, take a look at the article published in "Focus Sciences" of CNRS Le Journal.

Photo_COMPLEAT
© Christian Morel / LIPhy / CNRS Images

Contact

Didier Mondelain
didier.mondelainatuniv-grenoble-alpes.fr (didier[dot]mondelain[at]univ-grenoble-alpes[dot]fr)

Scrutinizing the skeleton of our cells, an essential issue for health

Publication Research On November 28, 2024

By combining a numerical modeling approach with experiments in both structural and cellular biology, the APERTuRe project has led to a better understanding of the dynamics of a protein network in the cytoplasm of our cells. These results could prove useful in the development of new drugs.

The project was coordinated by Karin John, a CNRS researcher at LIPhy. To find out more, take a look at the article published in "Focus Sciences" of CNRS Le Journal.

immunofluorescence

Contact

Karin John
karin.johnatuniv-grenoble-alpes.fr (karin[dot]john[at]univ-grenoble-alpes[dot]fr)

Hydrogen dimer detected at room temperature at LIPhy

Publication Research On September 26, 2024

While this dimer is one of the simplest molecular complexes, it is also one of the most fragile. Its detection at room temperature took the community by surprise.

We talk about it in Chemistry World, a magazine published by the Royal Society of Chemistry!

The HOT article PCCP can be read here.

Partenaires

Référence:
H. Fleurbaey, S. Kassi  and  A. Campargue, Room temperature detection of the (H2)2 dimer. Physical Chemistry Chemical Physics 26, 21974-21981 (2024) doi:10.1039/D4CP02605E

Alain Campargue Hydrogen dimer

Caging bubbles to develop high-resolution microscopes

Publication Research On December 12, 2024

Bubbles are ubiquitous in many research applications, from ultrasound imaging to understanding volcanic eruptions. They are also excellent acoustic resonators, being very small in size compared to the wavelength of the sound they emit. These resonant sound waves contain information about the mechanical properties of materials in the immediate vicinity of the bubble. In a recent publication in Nature Communications, a collaboration between LIPhy's Optima and Move teams proposes to exploit this phenomenon to image a sample by moving a bubble in its vicinity.

To find out more, take a look at :

cage cubique

Contact

Emmanuel Bossy
emmanuel.bossyatuniv-grenoble-alpes.fr (emmanuel[dot]bossy[at]univ-grenoble-alpes[dot]fr)

The secrets of Toxoplasma gondii parasite movement revealed

Publication Research On November 21, 2024

In an article published in Nature Microbiology, scientists have deciphered the rapid gliding strategy of the parasitic microbe Toxoplasma gondii within the host organism's tissues. They show how the parasite is able to hold on tightly enough without sticking to its substrate to glide efficiently. By explaining how a minimal adhesion system is able to generate rapid movement within complex microenvironments, they open up perspectives for other models of cellular interactions.

To find out more, take a look at :

  • the news published on the CNRS Biologie website,
  • the scientific article published in Nature Microbiology.
toxoplasma

Contact

Isabelle Tardieux (IAB, Grenoble)
isabelle.tardieuxatinserm.fr (isabelle[dot]tardieux[at]inserm[dot]fr)

Galina Dubacheva (DCM, Grenoble)
galina.dubachevaatuniv-grenoble-alpes.fr (galina[dot]dubacheva[at]univ-grenoble-alpes[dot]fr)

Delphine Débarre (LIPhy, Grenoble)
delphine.debarreatuniv-grenoble-alpes.fr (delphine[dot]debarre[at]univ-grenoble-alpes[dot]fr)

 

Reference

L. Vigetti, B. Touquet, L. Bureau, D. Abdallah, I. Tardieux , D. Debarre, T. Rose, G. V. Dubacheva. Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility. Nature Microbiology 9, 3148 (2024)

When red blood cells go off the beaten track

Publication Research On November 25, 2024

A Franco-American collaboration has demonstrated that in the microcirculatory network, some red blood cells can take unexpected routes to get from one point to another. This experimental observation should lead to more precise modeling of the mechanisms of oxygenation and elimination of the residues of cellular activity within the blood network.

To find out more, take a look at :

Globules rouges

Contact

Gwennou Coupier (LIPhy)
gwennou.coupieratuniv-grenoble-alpes.fr (gwennou[dot]coupier[at]univ-grenoble-alpes[dot]fr)

Thomas Podgorski (LRP)
thomas.podgorskiatuniv-grenoble-alpes.fr (thomas[dot]podgorski[at]univ-grenoble-alpes[dot]fr)

Reference

M. Alonzo, N. J. Karst, T. Podgorski, J. B. Geddes, and G. Coupier. Spatio-temporal instabilities of blood flow in a model capillary network. Physical Review Fluids 9, 104401 (2024)

Towards the ultimate precision limits: how information bounds estimation

Publication Research On September 13, 2024

In this month’s issue of Nature Physics, Dorian Bouchet proposes a popular science article about the Fisher information. This quantity, which is a cornerstone in statistical estimation theory, also emerges an an important quantity in different areas of physics.

The full article can be read here.

Partenaires

Référence:
D. Bouchet, An unbreakable limit. Nature Physics 20, 1518 (2024)
doi:10.1038/s41567-024-02631-9

Dorian Bouchet target

Dissolution of a school of fish in a complex environment

Publication Research On July 18, 2024

Scientists at LIPhy have demonstrated the existence of a behavioral transition when the environment of zebrafish becomes too crowded, showing the extent to which the collective school structure resists the structural complexity of the surrounding environment.

Fish form schools in a wide variety of environments, from the open sea amid coral reefs to rocky rivers. Some natural environments are obstructed, it is therefore interesting to understand how well the collective structure of a shoal withstands the complexity of the environment. Scientists at LIPhy have demonstrated the existence of a behavioral transition when the environment of zebrafish becomes too crowded.

The study of collective movements provides a better understanding of the dynamic structures resulting from the self-organization of groups of individuals. The study of fish schools is part of this approach. The schooling of fish is remarkable because it occurs in a wide variety of environments, from the open sea to coral reefs. Previous research has focused on the study of schools in simple, unobstructed environments. In this work, a team from LIPhy used an approach combining experiment and modeling to study the impact of a complex environment on the collective organization of a school of fish. To do this, they followed the individual trajectories of a small group of zebrafish in the presence of variable obstacle densities. The structure of the school of fish proved quite resilient to the introduction of obstacles, maintaining an organization similar to that observed in the absence of obstacles. However, when the obstacles reach a critical density, the shoal structure disappears and the fish behave as if they were isolated, aligning themselves with the obstacles and no longer with their fellow fish. This density corresponds to a distance between obstacles close to the typical distance between fish in an undisturbed shoal, i.e. their natural social distance. Using a statistical model, the ingredients of this behavioral transition, from collective to independent, were analyzed in detail. The LIPhy team has shown that a complex environment can have a significant influence on the collective behavior of fish, and that social distance is critical for maintaining collective behavior in a complex environment. These results contribute to the emerging field of active and cognitive matter, and more broadly to the study of animal behavior and swarm robotics through biomimicry.

Partenaires

Reference : Behavioral transition of a fish school in a crowded environment, Bruno Ventéjou, Iris Magniez- -Papillon, Eric Bertin, Philippe Peyla, and Aurélie Dupont, Phys. Rev. E 109, 064403 – Published June 11, 2024, DOI: 10.1103/PhysRevE.109.064403, Open-access archives: arXiv

Videoclip: https://www.youtube.com/watch?v=8jW9zACDLj0&t=1s

CNRS communication: https://www.inp.cnrs.fr/fr/cnrsinfo/la-dissolution-dun-banc-de-poissons…

Bruno Ventéjou and Aurélie Dupont GA
Group of zebrafish swimming in a network of obstacles of varying density. Analysis of relative orientations between fish in cases of very low and very high obstacle density. Credits © benfilm

Relating rheology to microstructure dynamics in dense suspensions of soft particles

Publication Research On February 6, 2022

Dense suspensions of soft particles possess relatively complex rheological properties, such as the existence of a threshold stress to flow. A new statistical physics approach allows to obtain a tensor constitutive model from the dynamics of the soft particles of the suspension, and thus to link the rheology to the anisotropy of the microstructure.

The theoretical description of the rheology of dense suspensions of micrometric soft particles, in which thermal fluctuations are negligible, remains a very open field based mainly on direct numerical simulations of suspensions or on phenomenological macroscopic constitutive models. Starting from a simplified model of a two-dimensional dense suspension, researchers at LIPhy have proposed a statistical physics method to obtain a macroscopic constitutive model from the dynamics of the soft particles constituting the suspension.

The tensor constitutive model derived analytically in this way allows a continuous description of the suspensions in the same way as the already existing phenomenological models, while keeping a link with the scale of the constitutive entities. This constitutive model consists of a nonlinear evolution equation for the deviatoric part of the stress tensor. It allows to reproduce the existence of a threshold stress in the rheology of dense suspensions above the jamming density, and to describe a Bingham-type rheology at low shear rate. The tensor nature of the constitutive equation also allows the prediction of a threshold stress on the difference of the normal stresses.

The approach, which technically includes a number of approximations, is primarily aimed at obtaining a qualitative description of the phenomenology of dense suspensions of soft particles, and at relating the structure of the resulting equation to the ingredients of the microscopic dynamics of the suspension. Interestingly, the obtained constitutive equation also allows to address more complex and time-dependent protocols, such as the start or stop of shearing. In particular, relaxation after shear leads to a lower final stress for a stronger shear, in qualitative agreement with experiments. The model also reproduces the power-law decay of the shear rate in creep experiments, as well as the collapse of the storage modulus measured in parallel superposition protocols, in which a small sinusoidal strain is applied to a dense flowing suspension.

One of the main interests of this approach is that it allows one to link macroscopic rheology with microstructure. In particular, the approach predicts that the orientation of the anisotropy of the microstructure, which is governed by a competition between advection and contact elasticity, plays a key role in the flow properties.

Read more :

- Microscopic Theory for the Rheology of Jammed Soft Suspensions
Nicolas Cuny, Romain Mari, Eric Bertin
Physical Review Letters, Novembre 2021

- Dynamics of microstructure anisotropy and rheology of soft jammed suspensions
Nicolas Cuny, Eric Bertin, Romain Mari
Soft Matter, Janvier 2022

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