The interaction between macrophages and their environment affects their functioning

Publication / Research

On March 27, 2025

Macrophages are immune system cells that ingest and degrade microorganisms and cellular debris in a process called phagocytosis. In a study published in iScience, scientists show that the mechanical properties of the tissues surrounding macrophages influence phagocytosis, which in turn affects the way macrophages interact with their environment.

To find out more, take a look at :

the news published on the CNRS Biologie website,
the scientific article published in Nature Microbiology.

Date

On March 27, 2025

Contact

Isabelle Tardieux (IAB, Grenoble)
isabelle.tardieuxinserm.fr (isabelle[dot]tardieux[at]inserm[dot]fr)

Galina Dubacheva (DCM, Grenoble)
galina.dubachevauniv-grenoble-alpes.fr (galina[dot]dubacheva[at]univ-grenoble-alpes[dot]fr)

Delphine Débarre (LIPhy, Grenoble)
delphine.debarreuniv-grenoble-alpes.fr (delphine[dot]debarre[at]univ-grenoble-alpes[dot]fr)

Reference

L. Vigetti, B. Touquet, L. Bureau, D. Abdallah, I. Tardieux , D. Debarre, T. Rose, G. V. Dubacheva. Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility. Nature Microbiology 9, 3148 (2024)