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Artificial intelligence for optical measurements at the ultimate limit of precision

Publication Research On June 25, 2025

When light is scattered, how accurately can a measurement result be derived from that light? An international research team has explored the limits of what is possible using artificial intelligence.

To find out more, take a look at :

Measurement AI

Contact

Dorian BOUCHET
dorian.bouchetatuniv-grenoble-alpes.fr (dorian[dot]bouchet[at]univ-grenoble-alpes[dot]fr)

Reference

I. Starshynov, M. Weimar, L. M. Rachbauer, G. Hackl, D. Faccio, S. Rotter & D. Bouchet. Model-free estimation of the Cramér–Rao bound for deep learning microscopy in complex media. Nature Photonics 19, 593-600 (2025)

Universal Laws of Swimming – From Microbes to Whales

Publication Research On June 12, 2025

A scientific team from Grenoble, involving the Laboratoire interdisciplinaire de physique (LIPhy - CNRS/UGA) and the Centre Inria de l'UGA, has developed a groundbreaking computational model that reveals universal laws governing how creatures swim across vastly different sizes and environments — from microscopic bacteria to massive blue whales.

To find out more, take a look at :

Poisson

Contact

Bruno VENTEJOU
bruno.ventejouatuniv-grenoble-alpes.fr (bruno[dot]ventejou[at]univ-grenoble-alpes[dot]fr)

Reference

B. Ventéjou, T. Métivet, A. Dupont & P. Peyla. Universal Scaling Laws for a Generic Swimmer Model. Physical Review Letters 134(13), 134002 (2025)

When a soft mattress levitates the sleeper…

Publication Research On May 21, 2025

In a recent work, researchers show that particles entrained in a flow close to a deformable wall undergo a force that moves them slightly away from it, an important result for the general understanding of transport phenomena in biology.

To find out more, take a look at :

AFM

Contact

Abdelhamid MAALI (LOMA, Bordeaux)
abdelhamid.maaliatu-bordeaux.fr (abdelhamid[dot]maali[at]u-bordeaux[dot]fr)

Chaouqi MISBAH (LIPhy, Grenoble)
chaouqi.misbahatuniv-grenoble-alpes.fr (chaouqi[dot]misbah[at]univ-grenoble-alpes[dot]fr) 

Reference

H. Zhang, Z. Zhang, A. Jha, Y. Amarouchene, T. Salez, T. Guérin, C. Misbah and A. Maali. Direct Measurement of the Viscocapillary Lift Force near a Liquid Interface. Physical Review Letters 134(9), 094001 (2025)

How cyanobacteria's circadian clock reacts to cold

Publication Research On May 6, 2025

Cyanobacteria have an internal biological clock that rhythms their activities on a 24-hour cycle. Thanks to this finely regulated mechanism, these micro-organisms are able to anticipate day/night cycles. A study recently published in Scientific Reports looked at how this clock reacts when the temperature drops below 25°C, an important threshold for their physiology.

To find out more, take a look at :

Cyanobacteria

Contact

Irina MIHALCESCU
irina.mihalcescuatuniv-grenoble-alpes.fr (irina[dot]mihalcescu[at]univ-grenoble-alpes[dot]fr)

Reference

I. Mihalcescu, H. Kaji, H. Maruyama, J. Giraud, M. Van Melle-Gateau, B. Houchmandzadeh & H. Ito. When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation. Scientific Reports 15(1), 14884 (2025)

Laser microbubbles to test plant cell pressure

Publication Research On May 7, 2025

Using laser nucleation of microbubbles, physicists have shown that stomata, the miniature 'gates' that regulate light-dependent evaporation in vascular plants, remain inactive in non-vascular plants such as mosses.

To find out more, take a look at :

  • the news published on the CNRS Physique website,
  • the scientific article published in Proceedings of the National Academy of Science.
LaserHighSelaginella

Contact

Philippe MARMOTTANT
philippe.marmottantatuniv-grenoble-alpes.fr (philippe[dot]marmottant[at]univ-grenoble-alpes[dot]fr)

Reference

C. R. Brodersen, T. Brodribb, U. Hochberg, N. M. Holbrook, S. A. M. McAdam, J. Zailaa, B. Huggett, P. Marmottant. In-situ cavitation bubble manometry reveals lack of light-activated guard cell turgor modulation in bryophytes. Proceedings of the National Academy of Science 122 (13) e2419887122 (2025)

The interaction between macrophages and their environment affects their functioning

Publication Research On March 27, 2025

Macrophages are immune system cells that ingest and degrade microorganisms and cellular debris in a process called phagocytosis. In a study published in iScience, scientists show that the mechanical properties of the tissues surrounding macrophages influence phagocytosis, which in turn affects the way macrophages interact with their environment.

To find out more, take a look at :

  • the news published on the CNRS Biologie website,
  • the scientific article published in Nature Microbiology.
macrophages

Contact

Isabelle Tardieux (IAB, Grenoble)
isabelle.tardieuxatinserm.fr (isabelle[dot]tardieux[at]inserm[dot]fr)

Galina Dubacheva (DCM, Grenoble)
galina.dubachevaatuniv-grenoble-alpes.fr (galina[dot]dubacheva[at]univ-grenoble-alpes[dot]fr)

Delphine Débarre (LIPhy, Grenoble)
delphine.debarreatuniv-grenoble-alpes.fr (delphine[dot]debarre[at]univ-grenoble-alpes[dot]fr)

 

Reference

L. Vigetti, B. Touquet, L. Bureau, D. Abdallah, I. Tardieux , D. Debarre, T. Rose, G. V. Dubacheva. Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility. Nature Microbiology 9, 3148 (2024)

Recording the absorption spectra of gaseous molecules with an optical cavity of high finesse

Publication Research On February 20, 2025

To better understand the formation, composition and evolution of the atmospheres of terrestrial planets, scientists at LIPhy have developed spectrometers using optical cavity spectroscopy (CRDS). Their high sensitivity enables them to accurately record the absorption spectra of various molecules of atmospheric and planetary interest, such as dihydrogen, water or methane, mixed with carbon dioxide.

This research was funded in whole or in part by the French National Research Agency (ANR) under the COMPLEAT project, coordinated by Didier Mondelain, a CNRS researcher at LIPhy.

To find out more, take a look at the article published in "Focus Sciences" of CNRS Le Journal.

Photo_COMPLEAT
© Christian Morel / LIPhy / CNRS Images

Contact

Didier Mondelain
didier.mondelainatuniv-grenoble-alpes.fr (didier[dot]mondelain[at]univ-grenoble-alpes[dot]fr)

Scrutinizing the skeleton of our cells, an essential issue for health

Publication Research On November 28, 2024

By combining a numerical modeling approach with experiments in both structural and cellular biology, the APERTuRe project has led to a better understanding of the dynamics of a protein network in the cytoplasm of our cells. These results could prove useful in the development of new drugs.

The project was coordinated by Karin John, a CNRS researcher at LIPhy. To find out more, take a look at the article published in "Focus Sciences" of CNRS Le Journal.

immunofluorescence

Contact

Karin John
karin.johnatuniv-grenoble-alpes.fr (karin[dot]john[at]univ-grenoble-alpes[dot]fr)

Hydrogen dimer detected at room temperature at LIPhy

Publication Research On September 26, 2024

While this dimer is one of the simplest molecular complexes, it is also one of the most fragile. Its detection at room temperature took the community by surprise.

We talk about it in Chemistry World, a magazine published by the Royal Society of Chemistry!

The HOT article PCCP can be read here.

Partenaires

Référence:
H. Fleurbaey, S. Kassi  and  A. Campargue, Room temperature detection of the (H2)2 dimer. Physical Chemistry Chemical Physics 26, 21974-21981 (2024) doi:10.1039/D4CP02605E

Alain Campargue Hydrogen dimer

Caging bubbles to develop high-resolution microscopes

Publication Research On December 12, 2024

Bubbles are ubiquitous in many research applications, from ultrasound imaging to understanding volcanic eruptions. They are also excellent acoustic resonators, being very small in size compared to the wavelength of the sound they emit. These resonant sound waves contain information about the mechanical properties of materials in the immediate vicinity of the bubble. In a recent publication in Nature Communications, a collaboration between LIPhy's Optima and Move teams proposes to exploit this phenomenon to image a sample by moving a bubble in its vicinity.

To find out more, take a look at :

cage cubique

Contact

Emmanuel Bossy
emmanuel.bossyatuniv-grenoble-alpes.fr (emmanuel[dot]bossy[at]univ-grenoble-alpes[dot]fr)

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