Controlling ion channel activity with photoactivatable toxins

An international consortium including LIPhy researchers has developed a new technology to make these peptides photoactivatable, thus allowing precise spatiotemporal control of neuronal ion channels associated with excitability. This technology opens the door to new opportunities for translational research and therapeutic applications using light.

See online : In vivo spatiotemporal control of voltage-dependent ion channels using photoactivatable peptide toxins. Montnach J, Blömer LA, et al, Nat Commun. 2022 Jan 20;13(1):417.