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Controlling ion channel activity with photoactivatable toxins

Publication / Research

On February 9, 2022

Images d’un neurone pyramidal L5 par rapport à la position du spot d’illumination UV (405 nm)

Photoactivatable ion channel toxins derived from animal venoms provide the opportunity to control the activity of excitable cells with high spatiotemporal precision.

An international consortium including LIPhy researchers has developed a new technology to make these peptides photoactivatable, thus allowing precise spatiotemporal control of neuronal ion channels associated with excitability. This technology opens the door to new opportunities for translational research and therapeutic applications using light.

See online : In vivo spatiotemporal control of voltage-dependent ion channels using photoactivatable peptide toxins. Montnach J, Blömer LA, et al, Nat Commun. 2022 Jan 20;13(1):417.


On February 9, 2022

Submitted on February 14, 2024

Updated on February 14, 2024