Interaction between blood flow and biochemical signaling

Red blood cells (RBC) under flow can release ATP which reacts with endothelial receptors leading to the generation of calcium and nitric oxide to regulate blood flow. Simulations (in simple and complex geometry) are performed to analyze the coupling between RBCs and endothelial cells. Pathological situations are also considered, such as how blood aggregates and/or obstacles (such as lipid plaques) can affect blood flow regulation.