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Expression and function of small non-coding RNAs: gene regulation by the E. coli sigma factor RpoS
Stéphan Lacour
We are studying the global regulatory effects of RpoS and its cofactors (Crl and an uncharacterized protein) in E. coli K12. In particular, we are looking for antisense RNAs and non-coding RNAs (RNAseq) and transcription factors responsible for indirect gene regulation, including negative regulation. We are also trying to identify the core of the RpoS regulator (Run Off Micro Array, ChIP-seq) in order to determine the specific characteristics and properties of the DNA of promoters strictly dependent on RpoS.
Collaborations
Paolo Landini (Università degli Studi di Milano, Italy), Clelia Peano (ITB, National Research Council, Segrate (MI), Italy), Magne Osteris (Fasteris, Geneva, Switzerland)
Identification and characterization of small regulatory RNAs and transcription attenuators in E. coli
Stéphan Lacour, Alexandre Dawid
[Page under construction. Description coming soon...]
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