Functional imaging of ion channels

Our recent imaging technologies and methods opened the gate to the understanding of ion channels in the context of neuronal excitability and their implications in brain disease. In the team, we record optically, at high spatial and temporal resolution, neuronal electrical signals and ion influx, and we interpret these measurements in terms of ion channel activity using pharmacology and computer modeling. The research carried out with to the ANR grant Nav12RESCUE (2022-2026, coordinated by IPMC in Nice) brought new insights on channelopathies of the sodium channel Nav1.2 causing autism, thanks to the analysis of neurons in brain slices from mouse models. Our research will continue in the same line with the ANR grant CHLORZOWIL (2026-2029, coordinated by INCIA in Bordeaux), aimed at understand ion channel dysfunction associated with the syndrome of Williams-Beuren and with the ANR grant SynBin (2026-2029, coordinated by IBENS in Paris), aimed at understanding the complex diversity of synaptic contacts.