The scientific question that drives the MicroTiss team is how cells, which are spatially localized functional units, perceive the distant environment and use this information to self-organize and form functional tissues.
The team is particularly interested in the roles played by the propagation of mechanical signals, which propagate rapidly over long distances and in a directional manner unlike chemical signals, in tissue formation and regeneration

We therefore seek to determine:
  • How do mechanical perturbations propagate from one cell to another?
  • How these signals are perceived and interpreted by other cells?
  • How these signals are stored in space and time?
To answer these questions, we deploy a bottom-up strategy, from the elementary brick of a tissue (a pair of cells in contact) to millimeter-scale 3D model tissues.